Composed Sildenafil citrate was originally developed by a major pharmaceutical group as a possible treatment for hypertension and other heart and circulatory problems.

During clinical trials the drug showed disappointing results in selected lung conditions set out, but an unexpected side effect that may be useful: erection of the penis.

The pharmaceutical company behind the original compound started to look Sildenafil as a treatment for erectile dysfunction. The patent followed in 1996 and once the FDA has approved its use for erectile dysfunction, in 1998, Sildenafil has become the first medical compound ED.

Patents held for Sildenafil were the source of much legal wrangling worldwide. In some countries Sildenafil is built without a licence because of local government policies.

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Lead researcher Dr. David Hess, chairman of the Department of Neurology, Medical College of Georgia School of Medicine said that an old drug known as minocycline can reduce stroke damage in more ways inhibiting white blood cells and enzymes that, at least acute, can destroy brain tissue and blood vessels.

The antibiotic may also reduce the suicide cell in the minutes and hours after a stroke, which allows more cells to recover.

“It ‘a safe drug that is easy to give and tolerate, that gets in the brain well, and may reduce bleeding, the main side effect of tPA. We think it will hit smaller and better patient outcomes,” said Dr Hess.

TPA drugs is the only FDA-approved drug therapy for strokes. The team conducting a clinical trial that will study the drug in 60 patients with stroke in Georgia, Kentucky and Oregon say they consider the antibiotic will be a safe, effective adjunctive therapy for tPA, the only FDA-approved drug therapy for strokes.

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